Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD

TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated...

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Bibliographic Details
Published in:	Gut Vol. 74; no. 4; pp. 652 - 668
Main Authors:	Bamias, Giorgos, Menghini, Paola, Pizarro, Theresa T, Cominelli, Fabio
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2025 BMJ Publishing Group LTD
Subjects:	Amino acids Animals CROHN'S DISEASE CYTOKINES Gene polymorphism Humans Immune response Immunology Inflammation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - immunology Intestine Kinases Ligands Lymphoid cells Monoclonal antibodies Pathogenesis Proteins Recent advances in basic science Receptors, Tumor Necrosis Factor, Member 25 - antagonists & inhibitors Receptors, Tumor Necrosis Factor, Member 25 - immunology Receptors, Tumor Necrosis Factor, Member 25 - metabolism Receptors, Tumor Necrosis Factor, Member 25 - physiology Signal Transduction Stromal cells Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors Tumor Necrosis Factor Ligand Superfamily Member 15 - immunology Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Tumor Necrosis Factor Ligand Superfamily Member 15 - physiology Tumor necrosis factor receptors Tumor necrosis factor-TNF ULCERATIVE COLITIS ULCERATIVE COLITIS CROHN'S DISEASE CYTOKINES
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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