ER Stress and Autophagy

Eukaryotic cells respond to various types of stresses caused by changes in the extracellular environment. Intracellular factors, such as the accumulation of misfolded proteins in the endoplasmic reticulum (ER), also cause stress and activate the unfolded protein response (UPR), which induces the exp...

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Vydané v:Current molecular medicine Ročník 15; číslo 8; s. 735
Hlavní autori: Lee, W-S, Yoo, W-H, Chae, H-J
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands 01.09.2015
Predmet:
Animals
Apoptosis
Autophagy - drug effects
Calcium Signaling
Cell Survival
Drug Discovery
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum Stress - drug effects
Humans
Molecular Chaperones - metabolism
Signal Transduction
Thapsigargin - pharmacology
TOR Serine-Threonine Kinases - metabolism
Unfolded Protein Response
ISSN:1875-5666
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Popis
Shrnutí:Eukaryotic cells respond to various types of stresses caused by changes in the extracellular environment. Intracellular factors, such as the accumulation of misfolded proteins in the endoplasmic reticulum (ER), also cause stress and activate the unfolded protein response (UPR), which induces the expression of chaperones and proteins involved in the recovery process. However, if the stress is excessive or sustained, and ER function cannot be restored, the UPR triggers apoptosis, thereby removing the affected cell. It is now apparent that ER stress is also a potent trigger for autophagy, a self-degradative process that has an adaptive function. This review surveys the intersection of ER stress and autophagy and highlights the potential therapeutic implications thereof.
ISSN:1875-5666
DOI:10.2174/1566524015666150921105453