Albuminuria and Primary Open-Angle Glaucoma: the Singapore Chinese Eye Study (SCES)

AimsTo determine the association between albuminuria and primary open-angle glaucoma (POAG).MethodsParticipants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, m...

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Vydané v:British journal of ophthalmology Ročník 105; číslo 5; s. 669 - 673
Hlavní autori: Lim, Zhi Wei, Chee, Miao-Li, Thakur, Sahil, Fang, Xiaoling, Soh, Zhi Da, Majithia, Shivani, Teo, Zhen Ling, Sabanayagam, Charumathi, Wong, Tien Yin, Cheng, Ching-Yu, Tham, Yih-Chung
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England BMJ Publishing Group LTD 01.05.2021
Predmet:
Age
Alcohol use
Antihypertensives
Asymmetry
Blood pressure
Body mass index
Cornea
Creatinine
Diabetes
Epidemiology
Gender
Glaucoma
Hypertension
Kidney diseases
Public health
United States > US
Switzerland
Singapore
Glaucoma
Cornea
Optic Nerve
Retina
Inflammation
Ocular surface
Epidemiology
Trauma
Treatment Surgery
Iris
Macula
Angle
Imaging
Vision
Genetics
Public health
Tears
Intraocular pressure
ISSN:0007-1161, 1468-2079, 1468-2079
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Shrnutí:AimsTo determine the association between albuminuria and primary open-angle glaucoma (POAG).MethodsParticipants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on random spot urinary albumin and creatinine measurements. POAG was defined using the International Society of Geographic and Epidemiological Ophthalmology classification. Multivariable logistic regression with generalised estimating equation model was used to evaluate the association between albuminuria and POAG, while accounting for correlation between eyes.ResultsA total of 3009 Chinese adults (5963 eyes), aged 40–80 years, were included in this study, of which, 52 subjects (75 eyes) had POAG. Higher UACR (per 50 mg/g increase) was independently associated with POAG (OR=1.04, 95% CI 1.01 to 1.07, p=0.003) following adjustment for age, gender, intraocular pressure, diabetes mellitus, hyperlipidaemia, hypertension, anti-hypertensive medication, history of cardiovascular disease, current smoking status, alcohol intake, body mass index and estimated glomerular filtration rate. Further stratification revealed that individuals with macroalbuminuria were 8.00 times likely to have POAG (95% CI 2.97 to 21.54, p<0.001), compared with those with normoalbuminuria. Microalbuminuria was not significantly associated with POAG (OR=0.49, 95% CI 0.19 to 1.29, p=0.150). The association between macroalbuminuria and POAG remained significant among individuals who were diabetic (OR=9.89, 95% CI 2.49 to 39.30, p=0.001) and hypertensive (OR=8.39, 95% CI 3.07 to 22.94, p<0.001).ConclusionIn this population-based study of Chinese adults, albuminuria was independently associated with POAG. Our findings provide further understanding on the pathogenesis of POAG and may potentially help to better identify individuals at risk of POAG.
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ISSN:0007-1161
1468-2079
1468-2079
DOI:10.1136/bjophthalmol-2020-315920