STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.DesignThe expression of AIM2 an...

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Veröffentlicht in:	Gut Jg. 71; H. 8; S. 1515 - 1531
Hauptverfasser:	Dawson, Ruby E, Deswaerte, Virginie, West, Alison C, Tang, Ke, West, Alice J, Balic, Jesse J, Gearing, Linden J, Saad, Mohamed I, Yu, Liang, Wu, Yonghui, Bhathal, Prithi S, Kumar, Beena, Chakrabarti, Jayati T, Zavros, Yana, Oshima, Hiroko, Klinman, Dennis M, Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.08.2022 BMJ Publishing Group LTD
Schlagworte:	Animal models Apoptosis Biopsy Carcinogenesis Caspase-1 Cell adhesion & migration Cell migration Cytokines Deoxyribonucleic acid DNA Epithelial cells Epithelium Gastric cancer Gene expression Genetic engineering immunology Inflammasomes Inflammation Inflammatory diseases Innate immunity Interleukin 11 Medical research Melanoma molecular biology Pathogenesis Patients Pattern recognition Pattern recognition receptors Protein expression Proteins Sensors Stat3 protein Stomach Survival analysis Therapeutic targets Tumorigenesis Tumors Xenografts Singapore
ISSN:	0017-5749, 1468-3288, 1468-3288
Online-Zugang:	Volltext
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