309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial

BackgroundThe sentinel lymph node (SLN) is the first node to receive lymphatic drainage from the primary tumor and the site where naïve T cells are first primed. As such it is of great importance in initiating an effective anti-tumor immune response and an attractive target for immunomodulatory agen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal for immunotherapy of cancer Jg. 8; H. Suppl 3; S. A336
Hauptverfasser:	Notohardjo, Jessica, Pul, Kim van, Stam, Anita, Chondronasiou, Dafni, Lougheed, Sinead, Tol, Petrousjka van den, Jooss, Karin, Vuylsteke, Ronald, Eertwegh, Alfons van den, Gruijl, Tanja de
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BMJ Publishing Group LTD 01.11.2020 BMJ Publishing Group
Schlagworte:	Biopsy Immunomodulators Immunotherapy Lymphatic system Lymphocytes Melanoma Monoclonal antibodies Targeted cancer therapy
ISSN:	2051-1426
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!