309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial

BackgroundThe sentinel lymph node (SLN) is the first node to receive lymphatic drainage from the primary tumor and the site where naïve T cells are first primed. As such it is of great importance in initiating an effective anti-tumor immune response and an attractive target for immunomodulatory agen...

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Bibliographic Details

Published in:	Journal for immunotherapy of cancer Vol. 8; no. Suppl 3; p. A336
Main Authors:	Notohardjo, Jessica, Pul, Kim van, Stam, Anita, Chondronasiou, Dafni, Lougheed, Sinead, Tol, Petrousjka van den, Jooss, Karin, Vuylsteke, Ronald, Eertwegh, Alfons van den, Gruijl, Tanja de
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group LTD 01.11.2020 BMJ Publishing Group
Subjects:	Biopsy Immunomodulators Immunotherapy Lymphatic system Lymphocytes Melanoma Monoclonal antibodies Targeted cancer therapy
ISSN:	2051-1426
Online Access:	Get full text
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