Dynamics of replication origin over-activation

We determined replication patterns in cancer cells in which the controls that normally prevent excess replication were disrupted ("re-replicating cells"). Single-fiber analyses suggested that replication origins were activated at a higher frequency in re-replicating cells. However, nascent...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Fu, Haiqing, Redon, Christophe E, Utani, Koichi, Thakur, Bhushan, Jang, Sangmin, Marks, Anna B, Zhuang, Sophie, Lazar, Sarah B, Rao, Mishal, Mencer, Shira, Gross, Jacob M, Lorinc Pongor, Aladjem, Mirit I
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 28.01.2020 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Genomics Replication initiation Replication origins
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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