Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila

How evolutionary changes in genes and neurons encode species variation in complex motor behaviors are largely unknown. Here, we develop genetic tools that permit a neural circuit comparison between the model species and the closely-related species , who has undergone a lineage-specific loss of sine...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Ye, Dajia, Walsh, Justin T, Junker, Ian P, Ding, Yun
Format: Journal Article Paper
Sprache:Englisch
Veröffentlicht: United States Cold Spring Harbor Laboratory Press 23.01.2024
Cold Spring Harbor Laboratory
Ausgabe:1.1
Schlagworte:
Anatomy
Apoptosis
Axons
Courtship
Drosophila
Evolutionary Biology
Evolutionary genetics
Insects
Lability
Neural networks
Neurons
Pattern formation
Phylogeny
Sex determination
Song
Transcriptomics
ISSN:2692-8205, 2692-8205
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Zusammenfassung:How evolutionary changes in genes and neurons encode species variation in complex motor behaviors are largely unknown. Here, we develop genetic tools that permit a neural circuit comparison between the model species and the closely-related species , who has undergone a lineage-specific loss of sine song, one of the two major types of male courtship song in . Neuroanatomical comparison of song patterning neurons called TN1 across the phylogeny demonstrates a link between the loss of sine song and a reduction both in the number of TN1 neurons and the neurites serving the sine circuit connectivity. Optogenetic activation confirms that TN1 neurons in have lost the ability to drive sine song, while maintaining the ability to drive the singing wing posture. Single-cell transcriptomic comparison shows that specifically lacks a cell type corresponding to TN1A neurons, the TN1 subtype that is essential for sine song. Genetic and developmental manipulation reveals a functional divergence of the sex determination gene in to reduce TN1 number by promoting apoptosis. Our work illustrates the contribution of motor patterning circuits and cell type changes in behavioral evolution, and uncovers the evolutionary lability of sex determination genes to reconfigure the cellular makeup of neural circuits.
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Competing Interest Statement: The authors have declared no competing interest.
ISSN:2692-8205
2692-8205
DOI:10.1101/2024.01.23.576861