Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive gain in feedback loops might hyper- or hypo-excite motoneurons (MNs) and contribute to the pathogene...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Antonucci, Stefano, Caron, Guillaume, Dikwella, Natalie, Krishnamurty, Sruthi Sankari, Harster, Anthony, Zarrin, Hina, Tahanis, Aboud, Heuvel, Florian Olde, Danner, Simon M, Ludolph, Albert C, Grycz, Kamil, Bączyk, Marcin, Zytnicki, Daniel, Roselli, Francesco
Format:	Journal Article Paper
Sprache:	Englisch
Veröffentlicht:	United States Cold Spring Harbor Laboratory Press 20.12.2024 Cold Spring Harbor Laboratory
Ausgabe:	3.1
Schlagworte:	Adrenergic receptors Amyotrophic lateral sclerosis Down-regulation Electrical properties Excitability Feedback Motor neurons Neural networks Neuromodulation Neuroscience Receptor mechanisms Superoxide dismutase β-adrenergic neuromodulation Amyotrophic Lateral Sclerosis homeostatic feedbacks in vivo intracellular electrophysiology Spinal motoneurons transcriptomics GPCR channelome
ISSN:	2692-8205, 2692-8205
Online-Zugang:	Volltext
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