Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

Tissue-resident macrophages represent a group of highly responsive innate immune cells that acquire diverse functions by polarizing towards distinct subgroups. The subgroups of macrophages that reside in skeletal muscle (SKM) and their changes during aging are poorly characterized. By single-cell tr...

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Veröffentlicht in:	bioRxiv
Hauptverfasser:	Krasniewski, Linda K, Chakraborty, Papiya, Chang-Yi, Cui, Mazan-Mamczarz, Krystyna, Dunn, Christopher, Piao, Yulan, Fan, Jinshui, Shi, Changyou, Wallace, Tonya, Nguyen, Cuong, Rathbun, Isabelle A, Munk, Rachel, Tsitsipatis, Dimitrios, De, Supriyo, Sen, Payel, Ferrucci, Luigi, Gorospe, Myriam M
Format:	Paper
Sprache:	Englisch
Veröffentlicht:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.02.2022 Cold Spring Harbor Laboratory
Ausgabe:	1.1
Schlagworte:	Aging Cell Biology Cell surface Cytotoxicity Flow cytometry Inflammation Macrophages Musculoskeletal system Skeletal muscle Surface markers Transcriptomics macrophages polarization aging Skeletal muscle single-cell analysis
ISSN:	2692-8205, 2692-8205
Online-Zugang:	Volltext
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