Correlation between Gene Variants, Signaling Pathways, and Efficacy of Chemotherapy Drugs against Colon Cancers

Efficacies, toxicities, and resistance mechanisms of chemotherapy drugs, such as oxaliplatin and 5-fluorouracil (5-FU), vary widely among various categories and subcategories of colon cancers. By understanding the differences in the drug efficacy and resistance at the level of protein–protein networ...

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Bibliographic Details
Published in:Cancer informatics Vol. 2016; no. 15; pp. CIN.S34506 - 13
Main Authors: Tripathi, Swarnendu, Belkacemi, Louiza, Cheung, Margaret S., Bose, Rathindra N.
Format: Journal Article
Language:English
Published: London, England SAGE Publishing 01.01.2016
SAGE Publications
Sage Publications Ltd
Libertas Academica
Subjects:
Biotechnology
Cancer
Chemotherapy
Colon
Correlation
Drugs
Effectiveness
Genes
Original Research
oxaliplatin
KRAS
fluorouracil
chemotherapy
colon cancer
platinum drugs
ISSN:1176-9351, 1176-9351
Online Access:Get full text
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Summary:Efficacies, toxicities, and resistance mechanisms of chemotherapy drugs, such as oxaliplatin and 5-fluorouracil (5-FU), vary widely among various categories and subcategories of colon cancers. By understanding the differences in the drug efficacy and resistance at the level of protein–protein networks, we identified the correlation between the drug activity of oxaliplatin/5-FU and gene variations from the US National Cancer Institute-60 human cancer cell lines. The activity of either of these drugs is correlated with specific amino acid variant(s) of KRAS and other genes from the signaling pathways of colon cancer progression. We also discovered that the activity of a non-DNA-binding novel platinum drug, phosphaplatin, is comparable with oxaliplatin and 5-FU when it was tested against colon cancer cell lines. Our strategy that combines the knowledge from pharmacogenomics across cell lines with the molecular information from specific cancer cells is beneficial for predicting the outcome of a possible combination therapy for personalized treatment.
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ISSN:1176-9351
1176-9351
DOI:10.4137/CIN.S34506