Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography

To predict the development of glaucomatous visual field (VF) defects using Fourier-domain optical coherence tomography (FD OCT) measurements at baseline visit. Multicenter longitudinal observational study. Glaucoma suspects and preperimetric glaucoma participants in the Advanced Imaging for Glaucoma...

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Vydané v:American journal of ophthalmology Ročník 163; s. 29 - 37
Hlavní autori: Zhang, Xinbo, Loewen, Nils, Tan, Ou, Greenfield, David S., Schuman, Joel S., Varma, Rohit, Huang, David, Francis, Brian, Parrish, Richard K., Kishor, Krishna S., Quinn, Carolyn D., Iverson, Shawn, Kish, Nayara, Rebimbas, Jose, Weiss, Debra, Chopra, Vikas, Gil-Flamer, John, Linton, Judith, Ramos, Sylvia, Albeiruti, Eiyass, Noecker, Robert, DeRosa, Michael, Owens, Greg, Salay, Melessa, Truman, Kristy, Ladwig, Janice, Montalto, Michelle, Ishikawa, Hiroshi, Kagemann, Larry, Sehi, Mitra, Wang, Yimin, Wollstein, Gadi, Bi, Sharon, Chakraborty, Swati, DiLaura, Robert, Hu, Bo, Sell, John, Savatovsky, Eleonore, Sadda, Srinivas R., Konduru, Ranjith, Rakhshan, Elnaz, Srinivas, Sowmya, Lu, Ake T.H.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.03.2016
Elsevier Limited
Predmet:
Accuracy
Aged
Area Under Curve
Automation
Colleges & universities
Confidence intervals
Disease Progression
Female
Follow-Up Studies
Fourier Analysis
Glaucoma
Glaucoma, Open-Angle - diagnosis
Humans
Hypertension
Intraocular Pressure - physiology
Male
Middle Aged
Nerve Fibers - pathology
Ocular Hypertension - diagnosis
Ophthalmology
Optic Disk - pathology
Optic Nerve Diseases - diagnosis
Optics
Retinal Ganglion Cells - pathology
Software
Standard deviation
Tomography, Optical Coherence
Vision Disorders - diagnosis
Visual Field Tests
Visual Fields
ISSN:0002-9394, 1879-1891, 1879-1891
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Popis
Shrnutí:To predict the development of glaucomatous visual field (VF) defects using Fourier-domain optical coherence tomography (FD OCT) measurements at baseline visit. Multicenter longitudinal observational study. Glaucoma suspects and preperimetric glaucoma participants in the Advanced Imaging for Glaucoma Study. The optic disc, peripapillary retinal nerve fiber layer (NFL), and macular ganglion cell complex (GCC) were imaged with FD OCT. VF was assessed every 6 months. Conversion to perimetric glaucoma was defined by VF pattern standard deviation (PSD) or glaucoma hemifield test (GHT) outside normal limits on 3 consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model. Predictive accuracy was measured by the area under the receiver operating characteristic curve (AUC). Of 513 eyes (309 participants), 55 eyes (46 participants) experienced VF conversion during 41 ± 23 months of follow-up. Significant (P < .05, Cox regression) FD OCT risk factors included all GCC, NFL, and disc variables, except for horizontal cup-to-disc ratio. GCC focal loss volume (FLV) was the best single predictor of conversion (AUC = 0.753, P < .001 for test against AUC = 0.5). Those with borderline or abnormal GCC-FLV had a 4-fold increase in conversion risk after 6 years (Kaplan-Meier). Optimal prediction of conversion was obtained using the glaucoma composite conversion index (GCCI) based on a multivariate Cox regression model that included GCC-FLV, inferior NFL quadrant thickness, age, and VF PSD. GCCI significantly improved predictive accuracy (AUC = 0.783) over any single variable (P = .04). Reductions in NFL and GCC thickness can predict the development of glaucomatous VF loss in glaucoma suspects and preperimetric glaucoma patients.
Bibliografia:ObjectType-Article-1
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ISSN:0002-9394
1879-1891
1879-1891
DOI:10.1016/j.ajo.2015.11.029