Positive natural selection in the human lineage

Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until recently, the study of natural selection in humans has largely been restricted to comparing individual candidate genes to the...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 312; no. 5780; p. 1614
Main Authors: Sabeti, P C, Schaffner, S F, Fry, B, Lohmueller, J, Varilly, P, Shamovsky, O, Palma, A, Mikkelsen, T S, Altshuler, D, Lander, E S
Format: Journal Article
Language:English
Published: United States 16.06.2006
Subjects:
Alleles
Biological Evolution
Gene Frequency
Genetic Variation
Genetics, Population
Genome, Human
Haplotypes
Humans
Mutation
Polymorphism, Genetic
Selection, Genetic
Sequence Analysis, DNA
ISSN:1095-9203, 1095-9203
Online Access:Get more information
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Summary:Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species. Until recently, the study of natural selection in humans has largely been restricted to comparing individual candidate genes to theoretical expectations. The advent of genome-wide sequence and polymorphism data brings fundamental new tools to the study of natural selection. It is now possible to identify new candidates for selection and to reevaluate previous claims by comparison with empirical distributions of DNA sequence variation across the human genome and among populations. The flood of data and analytical methods, however, raises many new challenges. Here, we review approaches to detect positive natural selection, describe results from recent analyses of genome-wide data, and discuss the prospects and challenges ahead as we expand our understanding of the role of natural selection in shaping the human genome.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.1124309