Hydrocarbon Synthesis via Photoenzymatic Decarboxylation of Carboxylic Acids

A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In thi...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 141; no. 7; p. 3116
Main Authors: Zhang, Wuyuan, Ma, Ming, Huijbers, Mieke M E, Filonenko, Georgy A, Pidko, Evgeny A, van Schie, Morten, de Boer, Sabrina, Burek, Bastien O, Bloh, Jonathan Z, van Berkel, Willem J H, Smith, Wilson A, Hollmann, Frank
Format: Journal Article
Language:English
Published: United States 20.02.2019
ISSN:1520-5126, 1520-5126
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Summary:A recently discovered photodecarboxylase from Chlorella variabilis NC64A ( CvFAP) bears the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids. CvFAP, however, exhibits a clear preference for long-chain fatty acids thereby limiting its broad applicability. In this contribution, we demonstrate that the decoy molecule approach enables conversion of a broad range of carboxylic acids by filling up the vacant substrate access channel of the photodecarboxylase. These results not only demonstrate a practical application of a unique, photoactivated enzyme but also pave the way to selective production of short-chain alkanes from waste carboxylic acids under mild reaction conditions.
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ISSN:1520-5126
1520-5126
DOI:10.1021/jacs.8b12282