Iron and Cancer

This review explores the multifaceted role that iron has in cancer biology. Epidemiological studies have demonstrated an association between excess iron and increased cancer incidence and risk, while experimental studies have implicated iron in cancer initiation, tumor growth, and metastasis. The ro...

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Vydané v:Annual review of nutrition Ročník 38; s. 97
Hlavní autori: Torti, Suzy V, Manz, David H, Paul, Bibbin T, Blanchette-Farra, Nicole, Torti, Frank M
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 21.08.2018
Predmet:
Humans
Iron - administration & dosage
Iron Overload - complications
Neoplasms - epidemiology
Neoplasms - etiology
iron
cancer
carcinogenesis
cell death
ISSN:1545-4312, 1545-4312
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Popis
Shrnutí:This review explores the multifaceted role that iron has in cancer biology. Epidemiological studies have demonstrated an association between excess iron and increased cancer incidence and risk, while experimental studies have implicated iron in cancer initiation, tumor growth, and metastasis. The roles of iron in proliferation, metabolism, and metastasis underpin the association of iron with tumor growth and progression. Cancer cells exhibit an iron-seeking phenotype achieved through dysregulation of iron metabolic proteins. These changes are mediated, at least in part, by oncogenes and tumor suppressors. The dependence of cancer cells on iron has implications in a number of cell death pathways, including ferroptosis, an iron-dependent form of cell death. Uniquely, both iron excess and iron depletion can be utilized in anticancer therapies. Investigating the efficacy of these therapeutic approaches is an area of active research that promises substantial clinical impact.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1545-4312
1545-4312
DOI:10.1146/annurev-nutr-082117-051732