Cardiac Transverse Tubules in Physiology and Heart Failure

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowing efficient triggering of Ca release and initiation of contr...

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Veröffentlicht in:Annual review of physiology Jg. 84; S. 229
Hauptverfasser: Dibb, Katharine M, Louch, William E, Trafford, Andrew W
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 10.02.2022
Schlagworte:
Animals
Calcium - metabolism
Calcium Signaling - physiology
Cell Membrane - metabolism
Heart Failure
Humans
Mammals
Myocytes, Cardiac - physiology
Sarcolemma - metabolism
heart failure
cardiac dyad
JPH2
Bin1
calcium signaling
t-tubule
ISSN:1545-1585, 1545-1585
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Zusammenfassung:In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowing efficient triggering of Ca release and initiation of contraction. Once thought to serve as rather static enablers of excitation-contraction coupling, recent work has provided a newfound appreciation of the plasticity of the t-tubule network's structure and function. Indeed, t-tubules are now understood to support dynamic regulation of the heartbeat across a range of timescales, during all stages of life, in both health and disease. This review article aims to summarize these concepts, with consideration given to emerging t-tubule regulators and their targeting in future therapies.
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ISSN:1545-1585
1545-1585
DOI:10.1146/annurev-physiol-061121-040148