Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors co...

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Podrobná bibliografia
Vydané v:	The American journal of psychiatry Ročník 178; číslo 11; s. 1037
Hlavní autori:	Stevens, Jennifer S, Harnett, Nathaniel G, Lebois, Lauren A M, van Rooij, Sanne J H, Ely, Timothy D, Roeckner, Alyssa, Vincent, Nico, Beaudoin, Francesca L, An, Xinming, Zeng, Donglin, Neylan, Thomas C, Clifford, Gari D, Linnstaedt, Sarah D, Germine, Laura T, Rauch, Scott L, Lewandowski, Christopher, Storrow, Alan B, Hendry, Phyllis L, Sheikh, Sophia, Musey, Jr, Paul I, Haran, John P, Jones, Christopher W, Punches, Brittany E, Lyons, Michael S, Kurz, Michael C, McGrath, Meghan E, Pascual, Jose L, Datner, Elizabeth M, Chang, Anna M, Pearson, Claire, Peak, David A, Domeier, Robert M, O'Neil, Brian J, Rathlev, Niels K, Sanchez, Leon D, Pietrzak, Robert H, Joormann, Jutta, Barch, Deanna M, Pizzagalli, Diego A, Sheridan, John F, Luna, Beatriz, Harte, Steven E, Elliott, James M, Murty, Vishnu P, Jovanovic, Tanja, Bruce, Steven E, House, Stacey L, Kessler, Ronald C, Koenen, Karestan C, McLean, Samuel A, Ressler, Kerry J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.11.2021
Predmet:	Biological Variation, Individual Disease Susceptibility - etiology Disease Susceptibility - physiopathology Disease Susceptibility - psychology Emergency Service, Hospital - statistics & numerical data Female Functional Neuroimaging - methods Humans Life Change Events Magnetic Resonance Imaging - methods Male Mental Disorders - epidemiology Mental Disorders - etiology Mental Disorders - physiopathology Middle Aged Precipitating Factors Psychiatric Status Rating Scales Psychopathology Psychophysiology Trauma Severity Indices United States - epidemiology Wounds and Injuries - classification Wounds and Injuries - epidemiology Wounds and Injuries - psychology Wounds and Injuries - therapy United States Neuroimaging Cognitive Neuroscience Biological Markers Stress Posttraumatic Stress Disorder (PTSD)
ISSN:	1535-7228, 1535-7228
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Popis
Shrnutí:	Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations. A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments. Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms. These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1535-7228 1535-7228
DOI:	10.1176/appi.ajp.2021.20101526