Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis

Meningitis and encephalitis are leading global causes of central nervous system (CNS) disability and mortality. Current diagnostic workflows remain inefficient, requiring costly pathogen-specific assays and sometimes invasive surgical procedures. Meningitis and encephalitis are leading causes of cen...

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Bibliographic Details
Published in:	mBio Vol. 12; no. 4; p. e0114321
Main Authors:	Piantadosi, Anne, Mukerji, Shibani S., Ye, Simon, Leone, Michael J., Freimark, Lisa M., Park, Daniel, Adams, Gordon, Lemieux, Jacob, Kanjilal, Sanjat, Solomon, Isaac H., Ahmed, Asim A., Goldstein, Robert, Ganesh, Vijay, Ostrem, Bridget, Cummins, Kaelyn C., Thon, Jesse M., Kinsella, Cormac M., Rosenberg, Eric, Frosch, Matthew P., Goldberg, Marcia B., Cho, Tracey A., Sabeti, Pardis
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 31.08.2021
Subjects:	Acids Adult Aged Blood Central nervous system Central Nervous System Viral Diseases - cerebrospinal fluid Central Nervous System Viral Diseases - diagnosis Central Nervous System Viral Diseases - virology Cerebrospinal fluid Deoxyribonucleic acid DNA DNA viruses Encephalitis Encephalitis - cerebrospinal fluid Encephalitis - diagnosis Encephalitis - virology Female High-Throughput Nucleotide Sequencing - methods HIV Hospitals Human immunodeficiency virus Humans hybrid capture Infectious diseases Intensive care Laboratories Length of stay Leukocytes Male Meningitis Meningitis - cerebrospinal fluid Meningitis - diagnosis Meningitis - virology Metagenome metagenomic sequencing Metagenomics Metagenomics - methods Middle Aged Next-generation sequencing next-generation sequencing (NGS) Pathogens Prospective Studies Research Article Serology Varicella Viral infections Virology virus Viruses Viruses - classification Viruses - genetics Viruses - isolation & purification Viruses - pathogenicity metagenomic sequencing hybrid capture encephalitis next-generation sequencing (NGS) meningitis methylated DNA depletion virus
ISSN:	2150-7511, 2161-2129, 2150-7511
Online Access:	Get full text
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