COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown. Beyond neutralization, antibodies binding to their Fc receptors...

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Bibliographic Details
Published in:	mBio Vol. 12; no. 2
Main Authors:	Adeniji, Opeyemi S., Giron, Leila B., Purwar, Mansi, Zilberstein, Netanel F., Kulkarni, Abhijeet J., Shaikh, Maliha W., Balk, Robert A., Moy, James N., Forsyth, Christopher B., Liu, Qin, Dweep, Harsh, Kossenkov, Andrew, Weiner, David B., Keshavarzian, Ali, Landay, Alan, Abdel-Mohsen, Mohamed
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 20.04.2021
Subjects:	Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Specificity Antibody-Dependent Cell Cytotoxicity Antibody-dependent cell-mediated cytotoxicity Antigens Biomarkers - blood Case-Control Studies Cohort Studies Complement Activation Coronaviruses COVID-19 COVID-19 - etiology COVID-19 - immunology COVID-19 - virology Cytokines Cytotoxicity Fc receptors Female Hospitalization Humans Immune clearance Immunity, Innate Immunoglobulin Fc Fragments - immunology Inflammation Inflammation - blood Inflammation - etiology Inflammation - immunology Kruskal-Wallis test Male Mann-Whitney U test Middle Aged Observation Pandemics Pathogenesis Phagocytosis Receptors, Fc - immunology SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Spike Glycoprotein, Coronavirus - immunology Statistical analysis Vaccines COVID-19 Fc-mediated functions SARS-CoV-2 antibody inflammation
ISSN:	2150-7511, 2161-2129, 2150-7511
Online Access:	Get full text
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