Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. Observational study of UK Biobank participa...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association Jg. 323; H. 7; S. 636
Hauptverfasser:	Elliott, Joshua, Bodinier, Barbara, Bond, Tom A, Chadeau-Hyam, Marc, Evangelou, Evangelos, Moons, Karel G M, Dehghan, Abbas, Muller, David C, Elliott, Paul, Tzoulaki, Ioanna
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.02.2020
Schlagworte:	Adult Aged Case-Control Studies Coronary Artery Disease - genetics Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Middle Aged Multifactorial Inheritance Predictive Value of Tests Risk Risk Assessment - methods ROC Curve
ISSN:	1538-3598, 1538-3598
Online-Zugang:	Weitere Angaben
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