Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. To examine whether a polygenic risk score for CAD improves risk prediction beyond pooled cohort equations. Observational study of UK Biobank participa...

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Bibliographic Details
Published in:	JAMA : the journal of the American Medical Association Vol. 323; no. 7; p. 636
Main Authors:	Elliott, Joshua, Bodinier, Barbara, Bond, Tom A, Chadeau-Hyam, Marc, Evangelou, Evangelos, Moons, Karel G M, Dehghan, Abbas, Muller, David C, Elliott, Paul, Tzoulaki, Ioanna
Format:	Journal Article
Language:	English
Published:	United States 18.02.2020
Subjects:	Adult Aged Case-Control Studies Coronary Artery Disease - genetics Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Male Middle Aged Multifactorial Inheritance Predictive Value of Tests Risk Risk Assessment - methods ROC Curve
ISSN:	1538-3598, 1538-3598
Online Access:	Get more information
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