Antimicrobial resistance, virulence gene profiles, and molecular epidemiology of enterococcal isolates from patients with urinary tract infections in Shanghai, China

This study highlighted the critical need to understand Enterococcal strains causing UTIs in Shanghai, given their high prevalence. By assessing antimicrobial resistance profiles, virulence gene presence, and molecular epidemiology, the research offered valuable insights into the local epidemiology o...

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Veröffentlicht in:Microbiology spectrum Jg. 13; H. 1; S. e0121724
Hauptverfasser: Wu, Weiyi, Xiao, Shuzhen, Han, Lizhong, Wu, Qiong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Microbiology 07.01.2025
Schlagworte:
Adult
Aged
Anti-Bacterial Agents - pharmacology
Antimicrobial Chemotherapy
antimicrobial resistance
China - epidemiology
Drug Resistance, Bacterial - genetics
Enterococcus
Enterococcus - drug effects
Enterococcus - genetics
Enterococcus - isolation & purification
Enterococcus - pathogenicity
Enterococcus faecalis - drug effects
Enterococcus faecalis - genetics
Enterococcus faecalis - isolation & purification
Enterococcus faecalis - pathogenicity
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Enterococcus faecium - isolation & purification
Enterococcus faecium - pathogenicity
Female
Gram-Positive Bacterial Infections - epidemiology
Gram-Positive Bacterial Infections - microbiology
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
optrA
Research Article
urinary tract infections
Urinary Tract Infections - epidemiology
Urinary Tract Infections - microbiology
Virulence - genetics
Virulence Factors - genetics
virulence genes
Whole Genome Sequencing
China
Enterococcus
molecular epidemiology
optrA
antimicrobial resistance
urinary tract infections
virulence genes
ISSN:2165-0497, 2165-0497
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:This study highlighted the critical need to understand Enterococcal strains causing UTIs in Shanghai, given their high prevalence. By assessing antimicrobial resistance profiles, virulence gene presence, and molecular epidemiology, the research offered valuable insights into the local epidemiology of Enterococcus faecalis and Enterococcus. faecium . Identifying linezolid-resistant strains, all of which carry the optrA gene, including the first report of ST300 in China and recognizing dominant MLST types, such as ST16 and ST179 for E. faecalis and ST78 for E. faecium , are vital for guiding treatment and addressing the challenges these infections present. The data emphasize the need for ongoing surveillance and customized therapeutic approaches to combat emerging resistance and virulence factors in Enterococcal UTIs.
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01217-24