Analysis of Serum Haptoglobin Fucosylation in Hepatocellular Carcinoma and Liver Cirrhosis of Different Etiologies

We have developed herein a quantitative mass spectrometry-based approach to analyze the etiology-related alterations in fucosylation degree of serum haptoglobin in patients with liver cirrhosis and hepatocellular carcinoma (HCC). The three most common etiologies, including infection with hepatitis B...

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Bibliographic Details
Published in:	Journal of proteome research Vol. 13; no. 6; pp. 2986 - 2997
Main Authors:	Zhu, Jianhui, Lin, Zhenxin, Wu, Jing, Yin, Haidi, Dai, Jianliang, Feng, Ziding, Marrero, Jorge, Lubman, David M
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 06.06.2014
Subjects:	Aged Alcohol Drinking - adverse effects Biomarkers, Tumor - blood Carbohydrate Conformation Carbohydrate Sequence Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - etiology Case-Control Studies Diagnosis, Differential Early Detection of Cancer Female Fucose - metabolism Glycosylation Haptoglobins - metabolism Hepatitis B - blood Hepatitis B - complications Hepatitis C - blood Hepatitis C - complications Humans Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Cirrhosis - etiology Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - etiology Male Middle Aged Molecular Sequence Data Protein Processing, Post-Translational fucosylation Hepatocellular carcinoma biomarker haptoglobin MALDI liver cirrhosis
ISSN:	1535-3893, 1535-3907, 1535-3907
Online Access:	Get full text
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