Molecular insights into nucleocapsid assembly and transport in Marburg and Ebola viruses

This study provides crucial insights into the molecular mechanisms of nucleocapsid assembly and transport in filoviruses, specifically Marburg virus (MARV) and Ebola virus (EBOV). Using advanced live-cell imaging, we uncovered how the conserved PPxPxY motif in nucleoprotein (NP) mediates its interac...

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Bibliographic Details
Published in:	mBio Vol. 16; no. 11; p. e0155725
Main Authors:	Takamatsu, Yuki, Dolnik, Olga, Hirabayashi, Ai, Okamoto, Kenta, Kurashige, Tomomi, Shangfan, Hu, Oda Harumi, Catarina, Noda, Takeshi
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 12.11.2025
Subjects:	Animals Assembly and Maturation Assembly Sites and Cellular Compartments C-Terminus Cell Biology Cell Line Cell migration Ebola virus Ebolavirus Ebolavirus - genetics Ebolavirus - physiology Editor’s Pick Epidemics Filoviridae Genomes Humans live-cell imaging Marburg virus Marburgvirus - genetics Marburgvirus - physiology Measles Microscopy Molecular modelling NCLS Nucleocapsid Nucleocapsid - genetics Nucleocapsid - metabolism Nucleocapsid Proteins - genetics Nucleocapsid Proteins - metabolism Nucleocapsids Nucleoproteins - genetics Nucleoproteins - metabolism Plasmids Protein Binding protein structure-function Proteins Replication Research Article RNA polymerase Structural Proteins Transcription Factors Velocity Viral Assembly in Host Cells Viral Capsid Assembly Viral Nucleoproteins Viral Proteins Viral Proteins - genetics Viral Proteins - metabolism Viral Structure Virology Virus Assembly Virus Replication Viruses VP24 protein Africa Ebola virus NCLS protein structure-function Marburg virus live-cell imaging
ISSN:	2150-7511, 2161-2129, 2150-7511
Online Access:	Get full text
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