Directed, Palladium(II)-Catalyzed Enantioselective anti-Carboboration of Alkenyl Carbonyl Compounds

A substrate-directed enantioselective anti-carboboration reaction of alkenes has been developed, wherein a carbon-based nucleophile and a boron moiety are installed across the C=C bond through a 5-membered palladacycle intermediate. A preliminary result also shows it is possible to extend this react...

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Bibliographic Details
Published in:ACS catalysis Vol. 9; no. 4; p. 3260
Main Authors: Liu, Zhen, Li, Xiaohan, Zeng, Tian, Engle, Keary M
Format: Journal Article
Language:English
Published: United States 05.04.2019
Subjects:
MOX ligand
carboboration
palladium
directing group
enantioselective catalysis
ISSN:2155-5435, 2155-5435
Online Access:Get more information
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Summary:A substrate-directed enantioselective anti-carboboration reaction of alkenes has been developed, wherein a carbon-based nucleophile and a boron moiety are installed across the C=C bond through a 5-membered palladacycle intermediate. A preliminary result also shows it is possible to extend this reaction to alkenes that are more distal from the directing group and react via a 6-membered palladacycle. The reaction is promoted by a palladium(II) catalyst and a monodentate oxazoline ligand. A range of enantioenriched secondary alkylboronate products were obtained with moderate to high enantioselectivity that could be further upgraded by recrystallization. This work represents an efficient method to synthesize versatile and valuable alkylboronate building blocks. Building on an earlier mechanistic proposal by Peng, He, and Chen, a revised model is proposed to account for the stereoconvergent nature of this transformation.
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ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.9b00181