Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain

Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone (DDS), and their dihydrofolate reductase (DHFR) genotypes were determined. The in vitro data show that CCG is more potent than PM and that DDS...

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Vydáno v:	Antimicrobial agents and chemotherapy Ročník 42; číslo 1; s. 164
Hlavní autoři:	Nzila-Mounda, A, Mberu, E K, Sibley, C H, Plowe, C V, Winstanley, P A, Watkins, W M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.1998
Témata:	Animals Antimalarials - pharmacology Humans Kenya Malaria, Falciparum - drug therapy Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Point Mutation Proguanil - analogs & derivatives Proguanil - pharmacology Protozoan Proteins - drug effects Protozoan Proteins - genetics Pyrimethamine - pharmacology Sensitivity and Specificity Tetrahydrofolate Dehydrogenase - drug effects Tetrahydrofolate Dehydrogenase - genetics Triazines Kenya
ISSN:	0066-4804
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