Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain

Sixty-nine Kenyan Plasmodium falciparum field isolates were tested in vitro against pyrimethamine (PM), chlorcycloguanil (CCG), sulfadoxine (SD), and dapsone (DDS), and their dihydrofolate reductase (DHFR) genotypes were determined. The in vitro data show that CCG is more potent than PM and that DDS...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Antimicrobial agents and chemotherapy Ročník 42; číslo 1; s. 164
Hlavní autori:	Nzila-Mounda, A, Mberu, E K, Sibley, C H, Plowe, C V, Winstanley, P A, Watkins, W M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.01.1998
Predmet:	Animals Antimalarials - pharmacology Humans Kenya Malaria, Falciparum - drug therapy Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Point Mutation Proguanil - analogs & derivatives Proguanil - pharmacology Protozoan Proteins - drug effects Protozoan Proteins - genetics Pyrimethamine - pharmacology Sensitivity and Specificity Tetrahydrofolate Dehydrogenase - drug effects Tetrahydrofolate Dehydrogenase - genetics Triazines Kenya
ISSN:	0066-4804
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!