Dynamic behavior of P53-Mdm2-Wip1 gene regulatory network under the influence of time delay and noise

The tumor suppressor protein P53 can regulate the cell cycle, thereby preventing cell abnormalities. In this paper, we study the dynamic characteristics of the P53 network under the influence of time delay and noise, including stability and bifurcation. In order to study the influence of several fac...

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Veröffentlicht in:	Mathematical biosciences and engineering : MBE Jg. 20; H. 2; S. 2321 - 2347
Hauptverfasser:	Luo, LanJiang, Liu, Haihong, Yan, Fang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States AIMS Press 01.01.2023
Schlagworte:	bifurcation Computer Simulation Gene Regulatory Networks noise oscillation p53 network Protein Phosphatase 2C Proto-Oncogene Proteins c-maf time delay Tumor Suppressor Protein p53 - metabolism noise oscillation P53 network bifurcation time delay
ISSN:	1551-0018, 1551-0018
Online-Zugang:	Volltext
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