Cardiovascular Effects of Particulate Air Pollution

Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atheroge...

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Published in:Annual review of medicine Vol. 73; p. 393
Main Author: Bhatnagar, Aruni
Format: Journal Article
Language:English
Published: United States 27.01.2022
Subjects:
Air Pollutants - analysis
Air Pollutants - toxicity
Air Pollution - analysis
Air Pollution - statistics & numerical data
Animals
Cardiovascular Diseases - epidemiology
Humans
Lung
Particulate Matter - analysis
Particulate Matter - toxicity
ischemic heart disease
heart failure
atrial fibrillation
air pollution
insulin resistance
stroke
ISSN:1545-326X, 1545-326X
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Abstract Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
AbstractList Inhalation of fine particulate matter (PM2.5), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM2.5 has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM2.5 may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM2.5 is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.Inhalation of fine particulate matter (PM2.5), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM2.5 has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM2.5 may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM2.5 is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
Author Bhatnagar, Aruni
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  givenname: Aruni
  surname: Bhatnagar
  fullname: Bhatnagar, Aruni
  email: aruni@louisville.edu
  organization: Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA; email: aruni@louisville.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34644154$$D View this record in MEDLINE/PubMed
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Keywords ischemic heart disease
heart failure
atrial fibrillation
air pollution
insulin resistance
stroke
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Snippet Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM...
Inhalation of fine particulate matter (PM2.5), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to...
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SubjectTerms Air Pollutants - analysis
Air Pollutants - toxicity
Air Pollution - analysis
Air Pollution - statistics & numerical data
Animals
Cardiovascular Diseases - epidemiology
Humans
Lung
Particulate Matter - analysis
Particulate Matter - toxicity
Title Cardiovascular Effects of Particulate Air Pollution
URI https://www.ncbi.nlm.nih.gov/pubmed/34644154
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