Cardiovascular Effects of Particulate Air Pollution

Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atheroge...

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Bibliographic Details
Published in:Annual review of medicine Vol. 73; p. 393
Main Author: Bhatnagar, Aruni
Format: Journal Article
Language:English
Published: United States 27.01.2022
Subjects:
Air Pollutants - analysis
Air Pollutants - toxicity
Air Pollution - analysis
Air Pollution - statistics & numerical data
Animals
Cardiovascular Diseases - epidemiology
Humans
Lung
Particulate Matter - analysis
Particulate Matter - toxicity
ischemic heart disease
heart failure
atrial fibrillation
air pollution
insulin resistance
stroke
ISSN:1545-326X, 1545-326X
Online Access:Get more information
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Summary:Inhalation of fine particulate matter (PM ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.
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ISSN:1545-326X
1545-326X
DOI:10.1146/annurev-med-042220-011549