β-Hydroxybutyrate: A Signaling Metabolite

Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose...

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Vydané v:Annual review of nutrition Ročník 37; s. 51
Hlavní autori: Newman, John C, Verdin, Eric
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 21.08.2017
Predmet:
3-Hydroxybutyric Acid - metabolism
Aging
Animals
Epigenesis, Genetic
Humans
Liver - metabolism
Signal Transduction
Starvation
fasting
ketone bodies
metabolism
aging
epigenetics
ISSN:1545-4312, 1545-4312
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Popis
Shrnutí:Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs, such as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates. In addition to its activity as an energetic metabolite, BHB is increasingly understood to have cellular signaling functions. These signaling functions of BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and their actions may be relevant to a variety of human diseases as well as human aging.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1545-4312
1545-4312
DOI:10.1146/annurev-nutr-071816-064916