Associations between dietary iron intake from different sources and non-alcoholic fatty liver disease in adults

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) has become a worldwide public health problem. Current evidence on the association between dietary iron intake and the risk of NAFLD is limited. The present study aimed to investigate the associations of animal-derived dietary iron...

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Published in:Asia Pacific journal of clinical nutrition Vol. 33; no. 3; pp. 413 - 423
Main Authors: Chen, Chuanjing, Dong, Jianhong, Liu, Haihong, Ma, Teng, Sun, Yongye
Format: Journal Article
Language:English
Published: Clayton, Vic HEC Press 01.09.2024
APJCN
Subjects:
Adult
Blood pressure
Cross-Sectional Studies
Diabetes
Diet - methods
Diet - statistics & numerical data
Diseases
Evaluation
Fatty liver
Female
Food
Glucose
Heavy construction
Hepatitis
Humans
Hypertension
Interviews
Iron
Iron, Dietary - administration & dosage
Liver
Liver diseases
Male
Methodology
Middle Aged
National Health and Nutrition Examination Survey (U.S.)
Non-alcoholic Fatty Liver Disease - epidemiology
Nutrition
Nutrition Surveys
Original
Respiration
Secondary schools
United States - epidemiology
Womens health
Young Adult
United States
United States > US
National Health and Nutrition Examination Survey (NHANES)
non-alcoholic fatty liver disease (NAFLD)
dietary intake
plant-derived iron
animal-derived iron
ISSN:0964-7058, 1440-6047, 1440-6047
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Summary:Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) has become a worldwide public health problem. Current evidence on the association between dietary iron intake and the risk of NAFLD is limited. The present study aimed to investigate the associations of animal-derived dietary iron (ADDI) intake, plant-derived dietary iron (PDDI) intake, and the ratio of PDDI:ADDI with NAFLD risk among U.S. adult population. Methods and Study Design: This was a repeated cross-sectional study. Data were collected from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. NAFLD was defined as a United States Fatty Lives Index >=30, and dietary iron intake was assessed through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were applied to examine the associations between dietary iron intake from different sources and NAFLD risk. Results: A total of 9478 participants aged >=20 years were enrolled in the present study. After adjustment for multiple confounding factors, relative to the lowest quartile, the odds ratio (OR) and 95% confidence interval (CI) of NAFLD for the highest quartile was 1.01(95% CI, 0.82-1.24) for ADDI intake, 0.82 (95% CI, 0.64-0.99) for PDDI intake, and 1.00 (95% CI, 0.81-1.24) for the PDDI: ADDI intake ratio. In stratified analysis by sex and age, the significantly negative associations of PDDI intake with NAFLD was ob- served in women and participants older than 45 years. Dose-response analyses indicated that NAFLD was negatively associated with PDDI intake in a non-linear manner. Conclusions: PDDI intake was negatively associated with NAFLD in U.S. adults.
Bibliography:Informit, Melbourne (Vic)
Asia Pacific Journal of Clinical Nutrition, Vol. 33, No. 3, Aug 2024, 413-423
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0964-7058
1440-6047
1440-6047
DOI:10.6133/apjcn.202409_33(3).0012