In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs

The potency of antimalarial dihydrofolate reductase inhibitors, alone and in synergistic combination with dihydropteroate synthetase inhibitors, against the Kenyan K39 strain of Plasmodium falciparum (pyrimethamine resistant) and against normal replicating human bone marrow cells in in vitro culture...

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Vydáno v:	Antimicrobial agents and chemotherapy Ročník 39; číslo 4; s. 948
Hlavní autoři:	Winstanley, P A, Mberu, E K, Szwandt, I S, Breckenridge, A M, Watkins, W M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.1995
Témata:	Animals Dapsone - pharmacology Dihydropteroate Synthase - antagonists & inhibitors Drug Combinations Drug Synergism Folic Acid Antagonists - pharmacology Granulocytes - drug effects Hematopoietic Stem Cells - drug effects Humans Plasmodium falciparum - drug effects Proguanil - analogs & derivatives Proguanil - pharmacology
ISSN:	0066-4804
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