Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information

Sensitive and high-resolution chromatographic-driven metabonomomics studies experienced major growth with the aid of new analytical technologies and bioinformatics software packages. Hence, data collections by LC-MS and data analyses by multivariate statistical methods are by far the most straightfo...

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Bibliographic Details

Published in:	Analytical chemistry (Washington) Vol. 80; no. 4; p. 1280
Main Authors:	Chen, Jing, Zhao, Xinjie, Fritsche, Jens, Yin, Peiyuan, Schmitt-Kopplin, Philippe, Wang, Wenzhao, Lu, Xin, Häring, Hans Ulrich, Schleicher, Erwin D, Lehmann, Rainer, Xu, Guowang
Format:	Journal Article
Language:	English
Published:	United States 15.02.2008
Subjects:	Biomarkers - chemistry Biomarkers - urine Chromatography, High Pressure Liquid - methods Cohort Studies Diabetes Mellitus - pathology Diabetes Mellitus - urine Gas Chromatography-Mass Spectrometry - methods Humans Isomerism Multivariate Analysis Reproducibility of Results Risk Assessment Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
ISSN:	0003-2700
Online Access:	Get more information
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