High-Throughput Glycomic Methods

Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and poten...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Chemical reviews Ročník 122; číslo 20; s. 15865
Hlavní autoři: Trbojević-Akmačić, Irena, Lageveen-Kammeijer, Guinevere S M, Heijs, Bram, Petrović, Tea, Deriš, Helena, Wuhrer, Manfred, Lauc, Gordan
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 26.10.2022
Témata:
Glycomics - methods
Glycosylation
Polysaccharides - chemistry
ISSN:1520-6890, 1520-6890
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as well as to identify genes and other factors that govern glycosylation. This challenging endeavor requires highly robust, sensitive, and potentially automatable analytical technologies for the analysis of hundreds or thousands of glycomes in a timely manner (termed high-throughput glycomics). This review provides a historic overview as well as highlights recent developments and challenges of glycomic profiling by the most prominent high-throughput glycomic approaches, with -glycosylation analysis as the focal point. It describes the current state-of-the-art regarding levels of characterization and most widely used technologies, selected applications of high-throughput glycomics in deciphering glycosylation process in healthy and disease states, as well as future perspectives.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1520-6890
1520-6890
DOI:10.1021/acs.chemrev.1c01031