Prevalence of Germline Alterations on Targeted Tumor-Normal Sequencing of Esophagogastric Cancer

IMPORTANCE: Among patients with esophagogastric cancers, only individuals who present with known features of heritable cancer syndromes are referred for genetic testing. Broader testing might identify additional patients with germline alterations. OBJECTIVES: To examine the prevalence of likely path...

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Vydané v:	JAMA Network Open Ročník 4; číslo 7; s. e2114753
Hlavní autori:	Ku, Geoffrey Y, Kemel, Yelena, Maron, Steve B, Chou, Joanne F, Ravichandran, Vignesh, Shameer, Zarina, Maio, Anna, Won, Elizabeth S, Kelsen, David P, Ilson, David H, Capanu, Marinela, Strong, Vivian E, Molena, Daniela, Sihag, Smita, Jones, David R, Coit, Daniel G, Tuvy, Yaelle, Cowie, Kendall, Solit, David B, Schultz, Nikolaus, Hechtman, Jaclyn F, Offit, Kenneth, Joseph, Vijai, Mandelker, Diana, Janjigian, Yelena Y, Stadler, Zsofia K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States American Medical Association 01.07.2021
Predmet:	Adolescent Adult Aged Aged, 80 and over Cross-Sectional Studies Esophageal cancer Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Female Gastric cancer Germ-Line Mutation - genetics Humans Male Middle Aged Oncology Online Only Original Investigation Prevalence Whole Genome Sequencing - methods Whole Genome Sequencing - statistics & numerical data
ISSN:	2574-3805, 2574-3805
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