Antibacterial and antifouling polymer brushes incorporating antimicrobial peptide

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated int...

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Bibliographic Details
Published in:	Bioconjugate chemistry Vol. 20; no. 1; p. 71
Main Authors:	Glinel, Karine, Jonas, Alain M, Jouenne, Thierry, Leprince, Jérôme, Galas, Ludovic, Huck, Wilhelm T S
Format:	Journal Article
Language:	English
Published:	United States 21.01.2009
Subjects:	Anti-Bacterial Agents - administration & dosage Coated Materials, Biocompatible - chemistry Drug Carriers - chemistry Gram-Positive Bacteria - drug effects Materials Testing Peptides - administration & dosage Polymethacrylic Acids - chemistry
ISSN:	1520-4812, 1520-4812
Online Access:	Get more information
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Summary:	Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1520-4812 1520-4812
DOI:	10.1021/bc800280u