High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole

Aspergillus fumigatus is the most frequent fungus found in the sputum of cystic fibrosis (CF) subjects. Itraconazole is prescribed for allergic bronchopulmonary aspergillosis (ABPA) or Aspergillus bronchitis in CF subjects. We hypothesized that A. fumigatus isolates in the sputum of CF subjects with...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 56; H. 2; S. 869
Hauptverfasser:	Burgel, Pierre-Régis, Baixench, Marie-Thérèse, Amsellem, Michaël, Audureau, Etienne, Chapron, Jeanne, Kanaan, Reem, Honoré, Isabelle, Dupouy-Camet, Jean, Dusser, Daniel, Klaassen, Corné H, Meis, Jacques F, Hubert, Dominique, Paugam, André
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2012
Schlagworte:	Adult Antifungal Agents - pharmacology Aspergillosis, Allergic Bronchopulmonary - complications Aspergillosis, Allergic Bronchopulmonary - drug therapy Aspergillosis, Allergic Bronchopulmonary - epidemiology Aspergillosis, Allergic Bronchopulmonary - microbiology Aspergillus fumigatus - drug effects Aspergillus fumigatus - genetics Aspergillus fumigatus - isolation & purification Azoles - pharmacology Cohort Studies Cystic Fibrosis - complications Cystic Fibrosis - drug therapy Cystic Fibrosis - epidemiology Cystic Fibrosis - microbiology Drug Resistance, Fungal Female Humans Itraconazole - pharmacology Itraconazole - therapeutic use Male Microbial Sensitivity Tests - methods Prevalence Sputum - microbiology Young Adult
ISSN:	1098-6596, 1098-6596
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