Transgenerational Epigenetic Inheritance

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in mult...

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Veröffentlicht in:Annual review of genetics Jg. 52; S. 21
Hauptverfasser: Bošković, Ana, Rando, Oliver J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 23.11.2018
Schlagworte:
DNA Methylation - genetics
Epigenesis, Genetic
Epigenomics - trends
Germ Cells - growth & development
Inheritance Patterns - genetics
development
germ cells
epigenetics
transgenerational inheritance
ISSN:1545-2948, 1545-2948
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Zusammenfassung:Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in multicellular organisms. In addition to surveying examples of epivariation that may arise stochastically or in response to unknown stimuli, we also discuss the induction of heritable epigenetic changes by genetic or environmental perturbations. Mechanistically, we discuss the increasingly well-understood molecular pathways responsible for epigenetic inheritance, with a focus on the unusual features of the germline epigenome.
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ISSN:1545-2948
1545-2948
DOI:10.1146/annurev-genet-120417-031404