Transgenerational Epigenetic Inheritance

Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in mult...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of genetics Vol. 52; p. 21
Main Authors: Bošković, Ana, Rando, Oliver J
Format: Journal Article
Language:English
Published: United States 23.11.2018
Subjects:
DNA Methylation - genetics
Epigenesis, Genetic
Epigenomics - trends
Germ Cells - growth & development
Inheritance Patterns - genetics
development
germ cells
epigenetics
transgenerational inheritance
ISSN:1545-2948, 1545-2948
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has been clear for decades that additional epigenetic information can be passed on to future generations. Here, we review major model systems for transgenerational epigenetic inheritance via the germline in multicellular organisms. In addition to surveying examples of epivariation that may arise stochastically or in response to unknown stimuli, we also discuss the induction of heritable epigenetic changes by genetic or environmental perturbations. Mechanistically, we discuss the increasingly well-understood molecular pathways responsible for epigenetic inheritance, with a focus on the unusual features of the germline epigenome.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1545-2948
1545-2948
DOI:10.1146/annurev-genet-120417-031404