Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning

L2 β-lactamases, serine-based class A β-lactamases expressed by , play a pivotal role in antimicrobial resistance (AMR). However, limited studies have been conducted on these important enzymes. To understand the coevolutionary dynamics of L2 β-lactamase, innovative computational methodologies, inclu...

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Vydané v:	Journal of chemical information and modeling Ročník 64; číslo 9; s. 3706
Hlavní autori:	Zhu, Yu, Gu, Jing, Zhao, Zhuoran, Chan, A W Edith, Mojica, Maria F, Hujer, Andrea M, Bonomo, Robert A, Haider, Shozeb
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 13.05.2024
Predmet:	beta-Lactamases - chemistry beta-Lactamases - metabolism Deep Learning Evolution, Molecular Molecular Dynamics Simulation Protein Conformation Stenotrophomonas maltophilia - enzymology
ISSN:	1549-960X, 1549-960X
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