Molecular epidemiology and clinical features of Klebsiella variicola bloodstream infection compared with infection with other Klebsiella pneumoniae species complex strains

Klebsiella variicola is increasingly recognized as an emerging pathogen commonly found in the environment and human gut. However, its clinical and microbiological characteristics remain poorly understood. This study provides a comprehensive analysis of K. variicola bloodstream infections (BSIs), com...

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Veröffentlicht in:Microbiology spectrum Jg. 13; H. 6; S. e0301724
Hauptverfasser: Ohno, Tatsuya, Harada, Sohei, Saito, Hiroki, Tanii, Rimi, Komori, Kohji, Kurosawa, Miki, Wakatake, Haruaki, Kanazawa, Minoru, Ohki, Uiri, Minoura, Ayu, Yamada, Mario, Kaneko, Satsuki, Anzai, Momoko, Tsutsui, Yuto, Kuhara, Asuka, Oyanagi, Tadatomo, Tanaka, Yosuke, Takemura, Hiromu, Takeuchi, Hiroaki, Kunishima, Hiroyuki
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Microbiology 03.06.2025
Schlagworte:
Adult
Aged
Aged, 80 and over
Bacteremia - epidemiology
Bacteremia - microbiology
bloodstream infections
Case-Control Studies
Clinical Microbiology
Female
Humans
hypervirulent
Japan - epidemiology
Klebsiella - classification
Klebsiella - genetics
Klebsiella - isolation & purification
Klebsiella - pathogenicity
Klebsiella Infections - epidemiology
Klebsiella Infections - microbiology
Klebsiella Infections - mortality
Klebsiella Infections - pathology
Klebsiella pneumoniae
Klebsiella pneumoniae - classification
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - isolation & purification
Klebsiella pneumoniae - pathogenicity
Klebsiella variicola
Liver Abscess - microbiology
Male
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
Research Article
Retrospective Studies
Virulence - genetics
Virulence Factors - genetics
Whole Genome Sequencing
Japan
bloodstream infections
molecular epidemiology
Klebsiella variicola
hypervirulent
Klebsiella pneumoniae
ISSN:2165-0497, 2165-0497
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Zusammenfassung:Klebsiella variicola is increasingly recognized as an emerging pathogen commonly found in the environment and human gut. However, its clinical and microbiological characteristics remain poorly understood. This study provides a comprehensive analysis of K. variicola bloodstream infections (BSIs), comparing clinical and genetic features with the closely related K. pneumoniae . We identified significant differences in the prevalence of virulence genes between the two species. Notably, we observed K. variicola causing disseminated liver abscesses, similar to hypervirulent K. pneumoniae strains. These findings have important implications for accurate species identification, informing treatment strategies, and improving patient outcomes in the face of this emerging infectious threat.
Bibliographie:ObjectType-Article-1
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S.H. reports receiving speaker payments from MSD, Shionogi, and Pfizer, and consulting fees from Shionogi, Pfizer, and Denka outside the submitted work. The other authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.03017-24