Recent Advances in Amphiphilic Polymer-Oligonucleotide Nanomaterials via Living/Controlled Polymerization Technologies

Over the past decade, the field of polymer-oligonucleotide nanomaterials has flourished because of the development of synthetic techniques, particularly living polymerization technologies, which provide access to polymers with well-defined architectures, precise molecular weights, and terminal or si...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioconjugate chemistry Jg. 30; H. 7; S. 1889
Hauptverfasser: Sun, Hao, Yang, Lu, Thompson, Matthew P, Schara, Steve, Cao, Wei, Choi, Wonmin, Hu, Ziying, Zang, Nanzhi, Tan, Weihong, Gianneschi, Nathan C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 17.07.2019
Schlagworte:
Animals
Chemistry Techniques, Synthetic - methods
Drug Delivery Systems
Humans
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Polymerization
Polymers - chemical synthesis
Polymers - chemistry
Surface-Active Agents - chemical synthesis
Surface-Active Agents - chemistry
ISSN:1520-4812, 1520-4812
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Over the past decade, the field of polymer-oligonucleotide nanomaterials has flourished because of the development of synthetic techniques, particularly living polymerization technologies, which provide access to polymers with well-defined architectures, precise molecular weights, and terminal or side-chain functionalities. Various "living" polymerization methods have empowered chemists with the ability to prepare functional polymer-oligonucleotide conjugates yielding a library of architectures, including linear diblock, comb, star, hyperbranched star, and gel morphologies. Since oligonucleotides are hydrophilic and synthetic polymers can be tailored with hydrophobicity, these amphiphilic polymer-oligonucleotide conjugates are capable of self-assembling into nanostructures with different shapes, leading to many high-value-added biomedical applications, such as drug delivery systems, gene regulation, and 3D-bioprinting. This review aims to highlight the main living polymerization approaches to polymer-oligonucleotide conjugates, including ring-opening metathesis polymerization, atom transfer radical polymerization (ATRP), reversible addition-fragmentation transfer polymerization (RAFT), and ring-opening polymerization of cyclic esters and -carboxyanhydride. The self-assembly properties and resulting applications of polymer-DNA hybrid materials are highlighted as well.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1520-4812
1520-4812
DOI:10.1021/acs.bioconjchem.9b00166