Fluorinating the Sugar and the Nucleotide: Exploring Fluorination Within GDP-Mannose Probes Using Chemoenzymatic Synthesis

Fluorinated glycans offer a prime opportunity to study the intricacies of their associated binding events with proteins, invoke resistance toward enzymatic hydrolysis, and modulate carbohydrate physicochemical properties. Sugar nucleotides are the key building blocks used by glycosyltransferases and...

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Bibliographic Details
Published in:JACS Au Vol. 5; no. 8; pp. 3994 - 4001
Main Authors: Dolan, Jonathan P., Evans, Sean T., Benckendorff, Caecilie M. M., Sari, Suat, Ní Cheallaigh, Aisling, Miller, Gavin J.
Format: Journal Article
Language:English
Published: United States American Chemical Society 25.08.2025
Subjects:
fluorination
chemical probe
glycan
sugar nucleotide
dehydrogenase
ISSN:2691-3704, 2691-3704
Online Access:Get full text
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