Multiphoton-excited luminescent lanthanide bioprobes: two- and three-photon cross sections of dipicolinate derivatives and binuclear helicates

Multiphoton excited luminescent properties of water-soluble Eu(III) and Tb(III) complexes with derivatives of dipicolinic acid functionalized with a polyoxyethylene pendant arm and terminal groups, [Eu(L(OMe))(3)](3-), [Eu(L(NH2))(3)](3-), and [Tb(L(OH))(3)](3-), as well as of binuclear helicates wi...

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Veröffentlicht in:The journal of physical chemistry. B Jg. 114; H. 8; S. 2932
Hauptverfasser: Eliseeva, Svetlana V, Auböck, Gerald, van Mourik, Frank, Cannizzo, Andrea, Song, Bo, Deiters, Emmanuel, Chauvin, Anne-Sophie, Chergui, Majed, Bünzli, Jean-Claude G
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 04.03.2010
Schlagworte:
Fluorescent Dyes - chemistry
Lanthanoid Series Elements - chemistry
Ligands
Luminescence
Microscopy, Fluorescence, Multiphoton
Organometallic Compounds - chemistry
Photons
Picolinic Acids - chemistry
ISSN:1520-5207, 1520-5207
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Zusammenfassung:Multiphoton excited luminescent properties of water-soluble Eu(III) and Tb(III) complexes with derivatives of dipicolinic acid functionalized with a polyoxyethylene pendant arm and terminal groups, [Eu(L(OMe))(3)](3-), [Eu(L(NH2))(3)](3-), and [Tb(L(OH))(3)](3-), as well as of binuclear helicates with overall composition [Ln(2)(L(CX))(3)] (X = 2, 5) are investigated. Characteristic emission from the (5)D(0) and (5)D(4) excited levels of Eu(III) and Tb(III), respectively, upon approximately 800 nm excitation results from three-photon absorption (3PA) for [Eu(L(OMe))(3)](3-), [Eu(L(NH2))(3)](3-), [Tb(L(OH))(3)](3-), and [Ln(2)(L(C2))(3)], while luminescence from [Eu(2)(L(C5))(3)] is induced by two-photon absorption (2PA) owing to its 1PA spectrum extending further into the visible. The 3PA cross sections have been determined and are the first ones reported for lanthanide complexes: (i) those of Eu(III) and Tb(III) bimetallic helicates [Ln(2)(L(C2))(3)] are 20 times larger compared to the corresponding values for tris(dipicolinates); (ii) derivatization of dipicolinic acid for Tb(III) complexes has almost no influence on the 3PA cross section; however, for Eu(III) complexes a approximately 2 times decrease is observed. The feasibility of [Eu(2)(L(C5))(3)] as multiphoton luminescence bioprobe is demonstrated by two-photon scanning microscopy imaging experiments on HeLa cells incubated with this bimetallic helicate.
Bibliographie:ObjectType-Article-1
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content type line 23
ISSN:1520-5207
1520-5207
DOI:10.1021/jp9090206