Exploring synergistic and antagonistic interactions in phage-antibiotic combinations against ESKAPE pathogens

In the face of escalating antimicrobial resistance, combining phages with antibiotics offers a promising avenue for treating infections unresponsive to traditional antibiotics. However, while studies have explored synergistic interactions, less attention has been given to potential antagonism and it...

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Veröffentlicht in:Microbiology spectrum Jg. 12; H. 10; S. e0042724
Hauptverfasser: Kunz Coyne, Ashlan J., Eshaya, Mirna, Bleick, Callan, Vader, Samantha, Biswas, Biswajit, Wilson, Melanie, Deschenes, Michael V., Alexander, Jose, Lehman, Susan M., Rybak, Michael J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Microbiology 31.07.2024
Schlagworte:
antagonism
antibiotic
bacteriophage
Bacteriophages
Enterococcus faecium
Pseudomonas aeruginosa
Research Article
Staphylococcus aureus
antibiotic
Enterococcus faecium
Pseudomonas aeruginosa
antagonism
bacteriophage
Staphylococcus aureus
ISSN:2165-0497, 2165-0497
Online-Zugang:Volltext
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Zusammenfassung:In the face of escalating antimicrobial resistance, combining phages with antibiotics offers a promising avenue for treating infections unresponsive to traditional antibiotics. However, while studies have explored synergistic interactions, less attention has been given to potential antagonism and its impact on phage growth kinetics. This research evaluates the interplay between phages and antibiotics, revealing both synergistic and antagonistic patterns across various bacterial strains and shedding light on the complex dynamics that influence treatment efficacy. Understanding these interactions is crucial for optimizing combination therapies and advancing phage therapy as a viable solution for combating antimicrobial resistance.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.00427-24