A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism

At present, neither basic research nor clinical studies have revealed the exact biological functions or mechanisms of action of individual oligosaccharides during development or in adulthood. Thus, it remains largely unknown whether human milk oligosaccharides could serve as effective therapeutics f...

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Veröffentlicht in:mBio Jg. 15; H. 4; S. e0029824
Hauptverfasser: Schalich, Kasey M., Buendia, Matthew A., Kaur, Harpreet, Choksi, Yash A., Washington, M. Kay, Codreanu, Gabriela S., Sherrod, Stacy D., McLean, John A., Peek, Jr, Richard M., Acra, Sari A., Townsend, Steven D., Yan, Fang
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Microbiology 10.04.2024
Schlagworte:
2′-fucosyllactose
Adult
Animals
Antibiotics
Bacteria
Bifidobacterium infantis
Bifidobacterium longum subsp. infantis
Breast milk
Colitis - prevention & control
Colitis, Ulcerative - metabolism
Colon
Digestive system
Drinking water
Fecal microflora
Feces
Gastrointestinal Microbiome
Gastrointestinal tract
Gut microbiota
Health care
Homeostasis
Host-Microbial Interactions
human milk oligosaccharide
Humans
Immune system
Inflammation
Inflammatory bowel disease
inflammatory bowel diseases
intestinal barrier
Intestinal microflora
Intestine
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Mice
Microbiomes
Microbiota
Milk, Human
Oligosaccharides
Oligosaccharides - metabolism
Oxidative stress
pantothenate
Pantothenic Acid - analogs & derivatives
Patients
Research Article
Tumor necrosis factor-TNF
Ulcerative colitis
the gut microbiota
inflammatory bowel diseases
intestinal barrier
2′-fucosyllactose
human milk oligosaccharide
pantothenate
Bifidobacterium longum subsp. infantis
ISSN:2150-7511, 2161-2129, 2150-7511
Online-Zugang:Volltext
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Zusammenfassung:At present, neither basic research nor clinical studies have revealed the exact biological functions or mechanisms of action of individual oligosaccharides during development or in adulthood. Thus, it remains largely unknown whether human milk oligosaccharides could serve as effective therapeutics for gastrointestinal-related diseases. Results from the present study uncover 2′-FL-driven alterations in bacterial metabolism and identify novel B. infantis -secreted metabolites following the consumption of 2′-FL, including pantothenol. This work further demonstrates a previously unrecognized role of pantothenate in significantly protecting the intestinal barrier against oxidative stress and mitigating colitis in adult mice. Remarkably, 2′-FL-enhanced bacterial metabolic pathways are found to be dysregulated in the fecal microbiota of ulcerative colitis patients. These novel metabolic pathways underlying the bioactivities of 2′-FL may lay a foundation for applying individual oligosaccharides for prophylactic intervention for diseases associated with impaired intestinal homeostasis.
Bibliographie:ObjectType-Article-1
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The authors declare no conflict of interest.
ISSN:2150-7511
2161-2129
2150-7511
DOI:10.1128/mbio.00298-24