Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

Human amylin, or islet amyloid polypeptide, is a peptide cosecreted with insulin by the beta cells of the pancreatic islets of Langerhans. The 37-residue, C-terminally amidated human amylin peptide derives from a proprotein that undergoes disulfide bond formation in the endoplasmic reticulum and is...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 47; no. 37; p. 9900
Main Authors:	Yonemoto, Isaac T, Kroon, Gerard J A, Dyson, H Jane, Balch, William E, Kelly, Jeffery W
Format:	Journal Article
Language:	English
Published:	United States 16.09.2008
Subjects:	Amino Acid Sequence Amyloid - chemical synthesis Amyloid - chemistry Amyloid - metabolism Chromatography, Gel Circular Dichroism Humans Islet Amyloid Polypeptide Kinetics Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular
ISSN:	1520-4995, 1520-4995
Online Access:	Get more information
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