Genetic and environmental contributions to stability and change in social inhibition across the adolescent and adult life span
Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such exa...
Uloženo v:
| Vydáno v: | Developmental psychology Ročník 58; číslo 8; s. 1585 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.08.2022
|
| ISSN: | 1939-0599, 1939-0599 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such examine their contributions to SI stability and change across adolescent and adult life span. We analyzed cohort-sequential longitudinal data from the Netherlands Twin Register (NTR), spanning a period of 25 years (Men (N, %): 17855, 37.4%; Age (Median, IQR): 19 years, 16-26 years; 7474 complete MZ twins and 8799 complete DZ twins). The data were organized into 7 age groups: < 14 (preadolescence), 15-16 (early adolescence), 17-18 (mid adolescence), 19-20 (late adolescence), 21-30 (young adulthood), 31-40 (adulthood), 41 + (middle-age-older adulthood). SI was assessed with the ASEBA-based proxy questionnaire. Phenotypic stability was established across the entire age range. Next, a longitudinal genetic simplex model was fitted to estimate the genetic and environmental contributions to the observed phenotypic stability. Results showed SI correlated well across follow-up of a single decade (.44 ≤ r ≤ .59) and moderately across the 25 years (.23 - .32) from adolescence to middle-age and older. Broad-sense heritability (h²) was between 40 and 48% across the 7 age groups. Additive and nonadditive genetic effects together explained most of the stability of SI across the life span (about 60-90% of the phenotypic correlation between ages), whereas environmental effects played a lesser role (about 10-40%). Concluding, SI, known to increase the risk of internalizing psychopathology, is phenotypically stable across the life span, which is largely attributable to genetic contributions to individual differences in SI. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
|---|---|
| AbstractList | Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such examine their contributions to SI stability and change across adolescent and adult life span. We analyzed cohort-sequential longitudinal data from the Netherlands Twin Register (NTR), spanning a period of 25 years (Men (N, %): 17855, 37.4%; Age (Median, IQR): 19 years, 16-26 years; 7474 complete MZ twins and 8799 complete DZ twins). The data were organized into 7 age groups: < 14 (preadolescence), 15-16 (early adolescence), 17-18 (mid adolescence), 19-20 (late adolescence), 21-30 (young adulthood), 31-40 (adulthood), 41 + (middle-age-older adulthood). SI was assessed with the ASEBA-based proxy questionnaire. Phenotypic stability was established across the entire age range. Next, a longitudinal genetic simplex model was fitted to estimate the genetic and environmental contributions to the observed phenotypic stability. Results showed SI correlated well across follow-up of a single decade (.44 ≤ r ≤ .59) and moderately across the 25 years (.23 - .32) from adolescence to middle-age and older. Broad-sense heritability (h²) was between 40 and 48% across the 7 age groups. Additive and nonadditive genetic effects together explained most of the stability of SI across the life span (about 60-90% of the phenotypic correlation between ages), whereas environmental effects played a lesser role (about 10-40%). Concluding, SI, known to increase the risk of internalizing psychopathology, is phenotypically stable across the life span, which is largely attributable to genetic contributions to individual differences in SI. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such examine their contributions to SI stability and change across adolescent and adult life span. We analyzed cohort-sequential longitudinal data from the Netherlands Twin Register (NTR), spanning a period of 25 years (Men (N, %): 17855, 37.4%; Age (Median, IQR): 19 years, 16-26 years; 7474 complete MZ twins and 8799 complete DZ twins). The data were organized into 7 age groups: < 14 (preadolescence), 15-16 (early adolescence), 17-18 (mid adolescence), 19-20 (late adolescence), 21-30 (young adulthood), 31-40 (adulthood), 41 + (middle-age-older adulthood). SI was assessed with the ASEBA-based proxy questionnaire. Phenotypic stability was established across the entire age range. Next, a longitudinal genetic simplex model was fitted to estimate the genetic and environmental contributions to the observed phenotypic stability. Results showed SI correlated well across follow-up of a single decade (.44 ≤ r ≤ .59) and moderately across the 25 years (.23 - .32) from adolescence to middle-age and older. Broad-sense heritability (h²) was between 40 and 48% across the 7 age groups. Additive and nonadditive genetic effects together explained most of the stability of SI across the life span (about 60-90% of the phenotypic correlation between ages), whereas environmental effects played a lesser role (about 10-40%). Concluding, SI, known to increase the risk of internalizing psychopathology, is phenotypically stable across the life span, which is largely attributable to genetic contributions to individual differences in SI. (PsycInfo Database Record (c) 2022 APA, all rights reserved). Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such examine their contributions to SI stability and change across adolescent and adult life span. We analyzed cohort-sequential longitudinal data from the Netherlands Twin Register (NTR), spanning a period of 25 years (Men (N, %): 17855, 37.4%; Age (Median, IQR): 19 years, 16-26 years; 7474 complete MZ twins and 8799 complete DZ twins). The data were organized into 7 age groups: < 14 (preadolescence), 15-16 (early adolescence), 17-18 (mid adolescence), 19-20 (late adolescence), 21-30 (young adulthood), 31-40 (adulthood), 41 + (middle-age-older adulthood). SI was assessed with the ASEBA-based proxy questionnaire. Phenotypic stability was established across the entire age range. Next, a longitudinal genetic simplex model was fitted to estimate the genetic and environmental contributions to the observed phenotypic stability. Results showed SI correlated well across follow-up of a single decade (.44 ≤ r ≤ .59) and moderately across the 25 years (.23 - .32) from adolescence to middle-age and older. Broad-sense heritability (h²) was between 40 and 48% across the 7 age groups. Additive and nonadditive genetic effects together explained most of the stability of SI across the life span (about 60-90% of the phenotypic correlation between ages), whereas environmental effects played a lesser role (about 10-40%). Concluding, SI, known to increase the risk of internalizing psychopathology, is phenotypically stable across the life span, which is largely attributable to genetic contributions to individual differences in SI. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
| Author | Boomsma, Dorret I De Geus, Eco J C Denollet, Johan Kupper, Nina Dolan, Conor V Li-Gao, Ruifang |
| Author_xml | – sequence: 1 givenname: Ruifang orcidid: 0000-0003-0650-1351 surname: Li-Gao fullname: Li-Gao, Ruifang organization: Center of Research on Psychology in Somatic Diseases (CoRPS) – sequence: 2 givenname: Dorret I orcidid: 0000-0002-7099-7972 surname: Boomsma fullname: Boomsma, Dorret I organization: Department of Biological Psychology – sequence: 3 givenname: Conor V surname: Dolan fullname: Dolan, Conor V organization: Department of Biological Psychology – sequence: 4 givenname: Eco J C orcidid: 0000-0001-6022-2666 surname: De Geus fullname: De Geus, Eco J C organization: Department of Biological Psychology – sequence: 5 givenname: Johan surname: Denollet fullname: Denollet, Johan organization: Center of Research on Psychology in Somatic Diseases (CoRPS) – sequence: 6 givenname: Nina surname: Kupper fullname: Kupper, Nina organization: Center of Research on Psychology in Somatic Diseases (CoRPS) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35511521$$D View this record in MEDLINE/PubMed |
| BookMark | eNpN0D1PwzAQBmALgegHLPwA5JElYMd1Eo-ogoJUiQXm6GJfqFFil9ip1IXfjilFYrobnvfV6Wbk1HmHhFxxdsuZKO8M7hhjXJTqhEy5EipjUqnTf_uEzEL4SGYhlDwnEyEl5zLnU_K1QofRagrOUHQ7O3jXo4vQUe1dHGwzRutdoNHTEKGxnY37A9YbcO9IraPBa5u8dRvb2B9NQQ8-pMwGKRjfYdCp8pACM3aRdrZFGrbgLshZC13Ay-Ock7fHh9flU7Z-WT0v79cZLEQVs5aXJZeLgiEDpbhuZCWUwkI3reSai1bJPAGBlQFmQFXQAm8NclOWhRAmn5Ob397t4D9HDLHubTqq68ChH0OdFwXj6T-VTPT6SMemR1NvB9vDsK__fpZ_A6E3cXQ |
| CitedBy_id | crossref_primary_10_1017_S0033291724000692 crossref_primary_10_1016_j_genhosppsych_2025_02_008 crossref_primary_10_1016_j_jpsychores_2024_111994 crossref_primary_10_1016_j_genhosppsych_2025_03_010 |
| ContentType | Journal Article |
| DBID | NPM 7X8 |
| DOI | 10.1037/dev0001379 |
| DatabaseName | PubMed MEDLINE - Academic |
| DatabaseTitle | PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Psychology |
| EISSN | 1939-0599 |
| ExternalDocumentID | 35511521 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: European Community; Seventh Framework Program (FP7) – fundername: European Science Foundation (ESF) – fundername: Neuroscience Amsterdam Research Institute – fundername: NIH HHS – fundername: Amsterdam Public Health Research Institute – fundername: NIMH NIH HHS – fundername: European Research Council (ERC) – fundername: Netherlands Organisation for Scientific Research – fundername: KNAW Academy – fundername: Avera Institute for Human Genetics |
| GroupedDBID | --- --Z -DZ -ET -~X 0R~ 29F 2KS 354 5GY 5RE 5VS 6P2 6PF 7RZ 85S AAIKC AAMNW AAWTL ABCQX ABIVO ABNCP ABOPQ ABPPZ ACGFO ACHQT ACNCT ACPQG ADMHG AEHFB ALMA_UNASSIGNED_HOLDINGS AWKKM AZXWR BKOMP CGNQK CS3 DU5 EPA F5P FTD HVGLF HZ~ ISO L7B LW5 NHB NPM O9- OMK OPA OVD P2P PQQKQ ROL RXW SES SPA TAE TAF TEORI TN5 TWZ UHB UPT VQA WH7 XZL YCJ YIF YIN YZZ Z5M ZCA ZPI 3KI 7X8 ABVOZ AETEA PHGZT PUEGO |
| ID | FETCH-LOGICAL-a438t-f17715460e0a991cb58399e6cbf51c13f9527153e8da0da98afa1fde1d77633d2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000790486600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1939-0599 |
| IngestDate | Sat Sep 27 20:41:30 EDT 2025 Wed Feb 19 02:25:21 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a438t-f17715460e0a991cb58399e6cbf51c13f9527153e8da0da98afa1fde1d77633d2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-0650-1351 0000-0002-7099-7972 0000-0001-6022-2666 |
| OpenAccessLink | https://doi.org/10.1037/dev0001379 |
| PMID | 35511521 |
| PQID | 2660100185 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2660100185 pubmed_primary_35511521 |
| PublicationCentury | 2000 |
| PublicationDate | 20220801 |
| PublicationDateYYYYMMDD | 2022-08-01 |
| PublicationDate_xml | – month: 08 year: 2022 text: 20220801 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Developmental psychology |
| PublicationTitleAlternate | Dev Psychol |
| PublicationYear | 2022 |
| SSID | ssj0014395 |
| Score | 2.4205108 |
| Snippet | Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1585 |
| Title | Genetic and environmental contributions to stability and change in social inhibition across the adolescent and adult life span |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35511521 https://www.proquest.com/docview/2660100185 |
| Volume | 58 |
| WOSCitedRecordID | wos000790486600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB7U9bAX34_1RQSvYZtms2lOIuLixWUPCnsraZNgQVq168Je_O1O0q7rSQQvpdAEymQy82Vm8g3AlfOqkmeCCpflPs2YU52oiDqEInggkYPM6NBsQo7HyXSqJm3ArW7LKpc2MRhqU-U-Rt5HRxJ5vqBEXL--Ud81ymdX2xYa69DhCGW8VsvpKouAzlY0WWVFPQ_Jkp6Uy76x8wB_5C_QMriY0fZ_f24HtlpwSW4abdiFNVvuQffbxi324dPTTONXoktDflxyw1mhaL3tflWTWUUQN4bK2UUY3NwQJkVJmjA7vj0XWSj4Ijr4WoJYkqwYosKsQO9BXgpnCZqu8gCeRnePt_e0bcFA9YAnM-qYlAiyhpGNNCJJXFQEVMoO88wJljPulIhxALeJ0ZHRKtFOM2csMxINFzfxIWyUVWmPgSjfv9ByNdR4QhOZUWyQxdowFB3naGd6cLmUbYoq7vMWurTVR52upNuDo2aB0teGiyNFuMQ8BDn5w-xT6Mb-8kIo3zuDjsMNbs9hM5_Pivr9IugOPseThy9mD9C5 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+and+environmental+contributions+to+stability+and+change+in+social+inhibition+across+the+adolescent+and+adult+life+span&rft.jtitle=Developmental+psychology&rft.au=Li-Gao%2C+Ruifang&rft.au=Boomsma%2C+Dorret+I&rft.au=Dolan%2C+Conor+V&rft.au=De+Geus%2C+Eco+J+C&rft.date=2022-08-01&rft.eissn=1939-0599&rft_id=info:doi/10.1037%2Fdev0001379&rft_id=info%3Apmid%2F35511521&rft_id=info%3Apmid%2F35511521&rft.externalDocID=35511521 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1939-0599&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1939-0599&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1939-0599&client=summon |