Emergence of glass-like behavior in Markov state models of protein folding dynamics

The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov state models. Borrowing techniques from the s-ensemble method, we argue th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 135; no. 15; p. 5501
Main Authors: Weber, Jeffrey K, Jack, Robert L, Pande, Vijay S
Format: Journal Article
Language:English
Published: United States 17.04.2013
Subjects:
Glass - chemistry
Markov Chains
Models, Molecular
Protein Folding
Protein Structure, Tertiary
Proteins - chemistry
ISSN:1520-5126, 1520-5126
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov state models. Borrowing techniques from the s-ensemble method, we argue that distinct active and inactive phases exist for protein folding dynamics, and that kinetics for specific systems can fall into either dynamical regime. We do not, however, observe a true glass transition in any system studied. We go on to discuss how these inactive and active phases might relate to general protein folding properties.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1520-5126
1520-5126
DOI:10.1021/ja4002663